AGENDA

SYMPOSIUM

Alcohol, Intestinal Bacterial Growth, Intestinal Permeability to Endotoxin, and Medical Consequences

Sponsors:
 
National Institute on Alcohol Abuse and Alcoholism (NIAAA), Office of Dietary Supplements (ODS), and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH)

Place:
 
DoubleTree Hotel and Executive Meeting Center, 1750 Rockville Pike Rockville, MD 20852 – Phone: 301-468-1100 – www.doubletreerockville.com

Date:
 
Wednesday, October 11, 2006

Time:
 
8:00 a.m. – 4:30 p.m.


8:00 – 8:30 a.m.
 

REGISTRATION

8:30 – 8:45 a.m.
 
Welcome and Opening Remarks
Sam Zakhari, Ph.D., NIAAA/NIH
Paul M. Coates, Ph.D., ODS/NIH
Stephen James, M.D., NIDDK/NIH

8:45 – 9:00 a.m.
 
Introduction to the Symposium
Vishnudutt Purohit, Ph.D., NIAAA/NIH

Session I:
 
Chairpersons: Christine Swanson, Ph.D., ODS/NIH
Elizabeth Kovacs, Ph.D., Loyola University, Chicago, IL

9:00 – 9:40 a.m.
 
Role of Endotoxin in Alcoholic and Non-Alcoholic Liver Injury
David A. Brenner, M.D., Columbia University Medical Center, New York, NY

9:40 – 10:20 a.m.
 
Alcohol, Immune System, and Intestinal Bacterial Growth
Mashkoor A. Choudhry, Ph.D., University of Alabama at Birmingham, Birmingham, AL

10:20 – 10:40 a.m.
 
BREAK

10:40 – 11:20 a.m.
 
Probiotics, Intestinal Bacterial Overgrowth, and Peptidoglycan
R. Balfour Sartor, M.D., University of North Carolina, Chapel Hill, NC

11:20 – 12:00 p.m.
 
The Leaky Epithelial Barrier in Intestinal Diseases
Jerrold R. Turner, Ph.D., University of Chicago, Chicago, IL

12:00 – 1:00 p.m.
 
LUNCH

Session II:
 
Chairpersons: Frank Hamilton, M.D., NIDDK/NIH
Gyongyi Szabo, M.D., Ph.D., University of Massachusetts, Worcester, MA

1:00 – 1:40 p.m.
 
Alcohol, Intestinal Permeability, and Endotoxemia
J. Christian Bode, M.D., and Christiane Bode, Ph.D., Hohenheim University, Stuttgart, Germany

1:40 – 2:20 p.m.
 
Effects of Acetaldehyde and L-glutamine on Intestinal Permeability to Endotoxin
Radhakrishna Rao, Ph.D., University of Tennessee, Memphis, TN

2:20 – 3:00 p.m.
 
Role of Zinc in Preserving Intestinal Integrity in Alcohol-Intoxicated Mice
James Kang, Ph.D., University of Louisville School of Medicine, Louisville, KY

3:00 – 3:20 p.m.
 
BREAK

3:20 – 4:00 p.m.
 
Effects of Nitric Oxide and Oats Supplementation on Alcohol-Induced Leaky Gut
Ali Keshavarzian, M.D., Rush University Medical Center, Chicago, IL

4:00 – 4:30 p.m.
 
Discussion Chairpersons: Ali Keshavarzian, M.D. and Radhakrishna Rao, Ph.D.

4:30 p.m.
 
ADJOURN


Organizer: Vishnudutt Purohit, Ph.D., Program Director, Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism/NIH, 5635 Fishers Lane, Room 2035, Bethesda, MD 20892-9304; Phone: (301) 443-2689; Fax: (301) 594-0673; E-mail: vpurohit@mail.nih.gov

Co-organizer: Christine Swanson, Ph.D., Program Director, Office of Dietary Supplements/NIH, 6100 Executive Boulevard, Room 3B01, MSC 7517, Bethesda, MD 20892-7517; Phone: (301) 435-2920; Fax: (301) 480-1845; E-mail: SwansonC@mail.nih.gov

Co-organizer: Frank Hamilton, M.D., Chief, Digestive Disease Program, Division of Digestive Disease and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases/NIH, 6707 Democracy Boulevard, MSC 5450, 2 Democracy Plaza, Room 669, Bethesda, MD 20892-5450; Phone: (301) 594-8877; Fax: (301) 480-8300; E-mail: hamiltonf@niddk.nih.gov